Tidligere var melatonin reseptbelagt og ikke mulig å fileå uten rekvisisjon fra lege, Adult men etter at melatonin ble tillatt for salg uten resept, har dette blitt et vanlig virkemiddel i reseptfri sovemedisin.Gentleman har ikke sett alvorlige bivirkninger eller avhengighet ved korttidsbruk av melatonin, og det regnes som trygt ved korttidsbehan
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